Dual Arc winner Enable heads thirteen entries for Saturday's Coral Eclipse at Sandown Park Racecourse.
Her trainer John Gosden - who won the race with Roaring Lion last year, has sidestepped both the Epsom Derby meeting and Royal Ascot to allow the five-year-old mare more time to ease herself back into training.
The daughter of Nathaniel has not run since landing the Breeders Cup Turf last November - some 245 days ago, but will now bid to win the same race her sire did seven years ago on her own route to a third trip to France later in the season.
She is currently priced no bigger than 11/10 favourite, after increasing support from punters, and will look to follow her father's achievements as only the second horse to win the Eclipse on their first start of the season.
Gosden along with Teddy Grimthorpe - racing manager to Prince Khalid Abdullah, are delighted with her pre-season preparation and believe the time is right to bring her back to the fold.
(Credit: Racing Post) The Newmarket trainer said: "She’s in good form. She worked under Frankie [Dettori] yesterday morning on the round gallop and I was very happy with it. The plan is to go for the Eclipse and we couldn't be happier with her."
"It’s her first run back and you know the main target is on the first Sunday in October. We’ll try and build to that but we’re happy with her.
"She’s showing her enjoyment in training and her eagerness. Her exuberant nature is back and she has slimmed down a bit. I couldn’t be more happy with her work on Saturday."
Her campaign will be centred around a third trip to Paris to conquer the Qatar Prix de l'Arc de Triomphe at Longchamp.
She will attempt to become the first horse in history to win Europe's biggest race three times, having just held on from the late charge of Sea Of Class in the French capital ten months ago.
Teddy Grimthorpe added: "We're looking forward to seeing her. All of her work suggests she has been back on track over the last two weeks. She looks like she's been enjoying it and has been moving very well under Frankie so from that point of view we couldn't be happier.
Speaking on the opposition, he added: "There's no such thing as a 'gimmie' in a Group One so we will have to see. She is in good form and we're looking forward to it."
Prince of Wales's winner Crystal Ocean was the biggest exclusion from the opening list of runners on Monday, but trainer Sir Michael Stoute will still be represented with Lockinge winner Mustashry and Brigadier Gerard scorer Regal Reality.
Aidan O'Brien has five potential runners in mind, including St James's Palace Stakes victor Circus Maximus and Prince Of Wales runner-up Magical - who was beaten by Enable in America back in November at the Breeders Cup meeting.
Hughie Morrison's Dante winner Telecaster will look to overturn a poor run in the Derby, whilst Zabeel Prince will bid for a first British Group One success after disappointing at Ascot last month for trainer Roger Varian.
Addeybb - a non runner at the Curragh at the weekend, Danceteria and Knight To Behold also feature in the field.